3-[5-(3-羟基丙基)-2-呋喃]-丙烷-1-醇合成路线 (共 12 条)
反应条件
1: With (S)-(-)-Indoline-2-carboxylic acid; hydroquinone in dichloromethane; N,N-dimethyl-formamide
T=20°C; asymmetric Diels-Alder reaction; P=6000600 Torr; 20 h;
2: With sodium tetrahydroborate in methanol
optical yield given as percent ee;
参考文献
Mimoto, Akiko; Nakano, Keiji; Ichikawa, Yoshiyasu; Kotsuki, Hiyoshizo
Heterocycles, 2010 , vol. 80, # 2 p. 799 - 804
反应条件
1: With sulfuric acid in dichloromethane
Friedel-Crafts reaction; 12 h;
2: With sodium tetrahydroborate in methanol
5 h;
参考文献
Wang, Hsing-Shiun; Yu, Shuchun Joyce
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 1051 - 1055