(9ci)-1H-苯并咪唑-1-乙腈合成路线 （共 8 条）
反应条件
1: sodium nitrite; acetic acid / water / 20 °C / Cooling with ice 2: hydroxylamine hydrochloride; potassium hydroxide / diethylene glycol dimethyl ether / 170 °C / Cooling with ice View Scheme
参考文献
BASILEA PHARMACEUTICA AG; POHLMANN, Jens; BACHMANN, Felix
Patent: WO2011/12577 A1, 2011 ;
反应条件
1: 1H-benzo[d]imidazole With potassium tert-butylate in N,N-dimethyl-formamide
T=20°C; 4 h;
2: alpha-bromoacetonitrile in N,N-dimethyl-formamide
3 h;
参考文献
N.V. ORGANON
Patent: WO2007/54480 A1, 2007 ;
Location in patent: Page/Page column 11 ;
WO 2007/054480 A1
反应条件
1: 1H-benzo[d]imidazole With potassium tert-butylate in N,N-dimethyl-formamide
T=20°C; 1 h;
2: alpha-bromoacetonitrile in N,N-dimethyl-formamide
3 h;
参考文献
AKZO NOBEL N.V.
Patent: US2007/112034 A1, 2007 ;
Location in patent: Page/Page column 4 ;
反应条件
sodium methylate
1.) MeOH, DMF, 2.) DMF, heating;
参考文献
Danan; Charon; Kirkiacharian; Bories; Loiseau
Farmaco, 1997 , vol. 52, # 4 p. 227 - 229
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
Reflux;
参考文献
Rad, Mohammad Navid Soltani; Khalafi-Nezhad, Ali; Divar, Masoumeh; Behrouz, Somayeh
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 9 p. 1943 - 1954
反应条件
in acetonitrile
T=20°C; 24 h; Darkness; regioselective reaction;
参考文献
Rivera, Augusto; Maldonado, Mauricio; Rios-Motta, Jaime
Molecules, 2012 , vol. 17, # 7 p. 8578 - 8586
反应条件
potassium hydroxide; dimethyl sulfoxide
T=0°C;
参考文献
Ram, Vishnu J.; Nath, Mahendra; Shukla
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 16 p. 2137 - 2140
反应条件
acetic acid; sodium nitrite in water
T=20°C; Cooling with ice;
参考文献
BASILEA PHARMACEUTICA AG; POHLMANN, Jens; BACHMANN, Felix
Patent: WO2011/12577 A1, 2011 ;
Location in patent: Page/Page column 29; 30; 31 ;
