1H-吡咯并[2,3-b]吡啶-3-乙腈合成路线 （共 7 条）
参考文献
Robinson; Robinson
Journal of the American Chemical Society, 1956 , vol. 78, p. 1247,1249
反应条件
1: With acetic acid in water; N,N-dimethyl-formamide
T=110°C; 8 h;
2: With potassium carbonate in water; N,N-dimethyl-formamide
参考文献
Pierce, Larry T.; Cahill, Michael M.; McCarthy, Florence O.
Tetrahedron, 2011 , vol. 67, # 25 p. 4601 - 4611
反应条件
in tetrahydrofuran; water
参考文献
American Home Products Corporation
Patent: US5710164 A1, 1998 ;
反应条件
acetic acid in water; N,N-dimethyl-formamide
T=110°C; Inert atmosphere;
参考文献
Van Zandt, Michael C.; Doan, Brian; Sawicki, Diane R.; Sredy, Janet; Podjarny, Alberto D.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 7 p. 2006 - 2008
参考文献
Robinson; Robinson
Journal of the American Chemical Society, 1956 , vol. 78, p. 1247,1249
反应条件
1.1: acetic acid / ethanol; water / 0.5 h / 0 °C
1.2: 18 h / 100 °C
1.3: 20 °C / pH 11
2.1: acetic acid / water; N,N-dimethyl-formamide / 8 h / 110 °C
View Scheme
参考文献
Pierce, Larry T.; Cahill, Michael M.; McCarthy, Florence O.
Tetrahedron, 2011 , vol. 67, # 25 p. 4601 - 4611
反应条件
sodium hydroxide; nickel; aluminium in ethanol
1 h; Ambient temperature;
参考文献
Ueroegdi, Laszlo; Barta-Szalai, Gizella; Kisfaludy, Lajos; Domany, Gyoergy; Csehi, Attila
Heterocycles, 1994 , vol. 37, # 3 p. 1807 - 1818
