甲基 3-(2-氯-6-氟苯基)-5-甲基异噁唑-4-羧酸合成路线 （共 7 条）
反应条件
1: acetoacetic acid methyl ester With sodium hydroxide in methanol T=0 - 5°C; pH=10; 0.5 h; 2: 2-chloro-6-fluoro-N-hydroxybenzimidoyl chloride in methanol T=0 - 20°C; pH=9; 2 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 3 p. 621 - 627
反应条件
1.1: hydroxylammonium sulfate / methanol / 0.5 h 1.2: 0.5 h / pH 8 - 9 / Reflux 2.1: chlorine / methanol / 0 - 5 °C 3.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 3.2: 2 h / 0 - 20 °C / pH 9 View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 3 p. 621 - 627
反应条件
1.1: chlorine / methanol / 0 - 5 °C 2.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 2.2: 2 h / 0 - 20 °C / pH 9 View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 3 p. 621 - 627
反应条件
(i) NH2OH, (ii) Cl2, CHCl3, (iii) /BRN= 506727/, MeOH; Multistep reaction;
参考文献
Journal of the Chemical Society. Perkin transactions 1, , p. 5976 - 5983
反应条件
potassium hydroxide in ethanol
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
in toluene 6 h; Reflux;
参考文献
4SC Discovery GmbH
Patent: US2012/196862 A1, 2012 ;
Location in patent: Page/Page column 14 ;
反应条件
1: aq. KOH / ethanol
2: (i) SOCl2, (ii) NH3, acetone
View Scheme
参考文献
Hanson; Long; Nayler; Stove
Journal of the Chemical Society. Perkin transactions 1, 1965 , p. 5976 - 5983
