2,4-二羟基-3,3-二甲基丁酰胺合成路线 （共 9 条）
反应条件
ammonia T=-60 - 20°C; Ring cleavage;
参考文献
Aquino, Fabrice; Pauling, Horst; Walther, Willy; Plattner, Dietmar A.; Bonrath, Werner
Synthesis, 2000 , # 5 p. 731 - 737
反应条件
ammonia; toluene-4-sulfonic acid in methanol T=250°C; P=7220 - 11400 Torr; 4 h; Heating;
参考文献
Barrios, Ivana; Camps, Pelayo; Comes-Franchini, Mauro; Munoz-Torrero, Diego; Ricci, Alfredo; Sanchez, Laura
Tetrahedron, 2003 , vol. 59, # 11 p. 1971 - 1979
反应条件
1: 14 percent Spectr. / p-TsOH*H2O / bis-(2-methoxy-ethyl) ether / 5 h / Heating 2: 84 percent / aq. NH3 / methanol / 14 h / 20 °C View Scheme
参考文献
Barrios, Ivana; Camps, Pelayo; Comes-Franchini, Mauro; Munoz-Torrero, Diego; Ricci, Alfredo; Sanchez, Laura
Tetrahedron, 2003 , vol. 59, # 11 p. 1971 - 1979
反应条件
1: 53 percent Spectr. / p-TsOH*H2O / bis-(2-methoxy-ethyl) ether / 15 h / Heating 2: 100 percent / methanol / 24 h / 20 °C 3: 14 percent Spectr. / p-TsOH*H2O / bis-(2-methoxy-ethyl) ether / 5 h / Heating 4: 84 percent / aq. NH3 / methanol / 14 h / 20 °C View Scheme
参考文献
Barrios, Ivana; Camps, Pelayo; Comes-Franchini, Mauro; Munoz-Torrero, Diego; Ricci, Alfredo; Sanchez, Laura
Tetrahedron, 2003 , vol. 59, # 11 p. 1971 - 1979
反应条件
1: 41 percent / p-TsOH*H2O / bis-(2-methoxy-ethyl) ether / 15 h / Heating 2: 84 percent / aq. NH3 / methanol / 14 h / 20 °C View Scheme
参考文献
Barrios, Ivana; Camps, Pelayo; Comes-Franchini, Mauro; Munoz-Torrero, Diego; Ricci, Alfredo; Sanchez, Laura
Tetrahedron, 2003 , vol. 59, # 11 p. 1971 - 1979
参考文献
Sakuragi; Kummerow
Journal of the American Chemical Society, 1956 , vol. 78, p. 838
参考文献
Sakuragi; Kummerow
Journal of the American Chemical Society, 1956 , vol. 78, p. 838
反应条件
toluene-4-sulfonic acid in dichloromethane; acetone T=20°C; Cyclization; 1 h;
参考文献
Aquino, Fabrice; Pauling, Horst; Walther, Willy; Plattner, Dietmar A.; Bonrath, Werner
Synthesis, 2000 , # 5 p. 731 - 737
反应条件
ammonia; toluene-4-sulfonic acid in methanol T=250°C; P=7220 - 11400 Torr; 4 h; Heating;
参考文献
Tetrahedron, , vol. 59, # 11 p. 1971 - 1979
