3(R)-羟基甲基-4-苄基吗啉合成路线 （共 3 条）
反应条件
triethylamine in tetrahydrofuran
T=20°C;
参考文献
MEDIVIR AB; AYESA, Susana; BELDA, Oscar; BJÖRKLUND, Catarina; NILSSON, Magnus; RUSSO, Francesco; SAHLBERG, Christer; WIKTELIUS, Daniel
Patent: WO2013/95275 A1, 2013 ;
Location in patent: Page/Page column 46 ;
反应条件
triethylamine in N,N-dimethyl-formamide
T=20°C; 3 h;
参考文献
MEDIVIR AB; AYESA, Susana; BELDA, Oscar; BJÖRKLUND, Catarina; NILSSON, Magnus; RUSSO, Francesco; SAHLBERG, Christer; WIKTELIUS, Daniel
Patent: WO2013/95275 A1, 2013 ;
Location in patent: Page/Page column 47 ;
反应条件
1.1: silver(l) oxide / tetrahydrofuran / 0.5 h / 20 °C
1.2: 48 h / 45 °C
2.1: palladium on carbon / methanol / 24 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
MEDIVIR AB; AYESA, Susana; BELDA, Oscar; BJÖRKLUND, Catarina; NILSSON, Magnus; RUSSO, Francesco; SAHLBERG, Christer; WIKTELIUS, Daniel
Patent: WO2013/95275 A1, 2013 ;
