1.1: 96 percent / copper powder / quinoline / 3 h / Heating 2.1: 96 percent / DMAP / acetonitrile / 0 - 20 °C 3.1: NBS; AIBN / CCl4 / 2.5 h / Heating 4.1: 5.37 g / nBuLi / tetrahydrofuran; hexane / 5 h / -78 °C 5.1: HCl / tetrahydrofuran; H2O / 2 h / 20 °C 5.2: 71 percent / HCl / ethyl acetate / 3 h / 0 °C 6.1: 96 percent / NaOH / ethanol; H2O / 1 h / 40 °C View Scheme

copper in quinoline 3 h; Heating;