4-硝基苯基-Β-D-乳糖苷合成路线 （共 15 条）
反应条件
Thermus nonproteolyticus HG102 E338A mutant; glycine; sodium hydroxide in aq. buffer T=45°C; pH=8.8; 48 h; Enzymatic reaction; Overall yield = 90 percent;
参考文献
Wei, Jinhua; Lv, Xun; Lue, Yang; Yang, Gangzhu; Fu, Lifeng; Yang, Liu; Wang, Jianjun; Gao, Jianhui; Cheng, Shuihong; Duan, Qian; Jin, Cheng; Li, Xuebing
European Journal of Organic Chemistry, 2013 , # 12 p. 2414 - 2419
反应条件
sodium methylate in methanol
参考文献
Roy, Rene; Tropper, Francois D.; Morrison, Tara; Boratynski, Janusz
Journal of the Chemical Society, Chemical Communications, 1991 , # 7 p. 536 - 538
反应条件
AbgGlu358Ala; ammonium bicarbonate buffer 8 h; Ambient temperature;
参考文献
Mackenzie; Wang; Antony; Warren; Withers
Journal of the American Chemical Society, 1998 , vol. 120, # 22 p. 5583 - 5584
反应条件
1: TBAHS; aq. Na2CO3 / CH2Cl2 / 3 h / 20 °C 2: NaOMe; MeOH View Scheme
参考文献
Wei, Jinhua; Lv, Xun; Lue, Yang; Yang, Gangzhu; Fu, Lifeng; Yang, Liu; Wang, Jianjun; Gao, Jianhui; Cheng, Shuihong; Duan, Qian; Jin, Cheng; Li, Xuebing
European Journal of Organic Chemistry, 2013 , # 12 p. 2414 - 2419
反应条件
1: 100 percent / HBr / acetic acid 2: TBAHS; aq. Na2CO3 / CH2Cl2 / 3 h / 20 °C 3: NaOMe; MeOH View Scheme
参考文献
Wei, Jinhua; Lv, Xun; Lue, Yang; Yang, Gangzhu; Fu, Lifeng; Yang, Liu; Wang, Jianjun; Gao, Jianhui; Cheng, Shuihong; Duan, Qian; Jin, Cheng; Li, Xuebing
European Journal of Organic Chemistry, 2013 , # 12 p. 2414 - 2419
反应条件
1: TBAHS; aq. Na2CO3 / CH2Cl2 / 3 h / 20 °C 2: NaOMe; MeOH View Scheme
参考文献
Roy, Rene; Tropper, Francois D.; Morrison, Tara; Boratynski, Janusz
Journal of the Chemical Society, Chemical Communications, 1991 , # 7 p. 536 - 538
反应条件
1: pyridine / 20 °C 2: hydrogen bromide; acetic acid / dichloromethane / 0 - 20 °C 3: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water; dichloromethane / 20 °C 4: methanol; sodium methylate / 20 °C / pH 10 - 11 View Scheme
参考文献
Wei, Jinhua; Lv, Xun; Lue, Yang; Yang, Gangzhu; Fu, Lifeng; Yang, Liu; Wang, Jianjun; Gao, Jianhui; Cheng, Shuihong; Duan, Qian; Jin, Cheng; Li, Xuebing
European Journal of Organic Chemistry, 2013 , # 12 p. 2414 - 2419
反应条件
1: methanol; sodium methylate / 20 °C 2: sodium hydroxide; Thermus nonproteolyticus HG102 E338A mutant; glycine / aq. buffer / 48 h / 45 °C / pH 8.8 / |Enzymatic reaction View Scheme
参考文献
Wei, Jinhua; Lv, Xun; Lue, Yang; Yang, Gangzhu; Fu, Lifeng; Yang, Liu; Wang, Jianjun; Gao, Jianhui; Cheng, Shuihong; Duan, Qian; Jin, Cheng; Li, Xuebing
European Journal of Organic Chemistry, 2013 , # 12 p. 2414 - 2419
反应条件
1: pyridine; hydrogen fluoride / -20 - 20 °C 2: methanol; sodium methylate / 20 °C 3: sodium hydroxide; Thermus nonproteolyticus HG102 E338A mutant; glycine / aq. buffer / 48 h / 45 °C / pH 8.8 / |Enzymatic reaction View Scheme
参考文献
Wei, Jinhua; Lv, Xun; Lue, Yang; Yang, Gangzhu; Fu, Lifeng; Yang, Liu; Wang, Jianjun; Gao, Jianhui; Cheng, Shuihong; Duan, Qian; Jin, Cheng; Li, Xuebing
European Journal of Organic Chemistry, 2013 , # 12 p. 2414 - 2419
反应条件
1: methanol; sodium methylate / 20 °C / pH 10 - 11 2: sodium hydroxide; Thermus nonproteolyticus HG102 E338A mutant; glycine / aq. buffer / 48 h / 45 °C / pH 8.8 / |Enzymatic reaction View Scheme
参考文献
Wei, Jinhua; Lv, Xun; Lue, Yang; Yang, Gangzhu; Fu, Lifeng; Yang, Liu; Wang, Jianjun; Gao, Jianhui; Cheng, Shuihong; Duan, Qian; Jin, Cheng; Li, Xuebing
European Journal of Organic Chemistry, 2013 , # 12 p. 2414 - 2419
