4-羟基-3-甲氧基苯甲腈合成路线 （共 46 条）
反应条件
sodium methylate; lauryl mercaptan in N,N-dimethyl-formamide T=100°C; 1 h;
参考文献
Tetrahedron, , vol. 59, # 33 p. 6363 - 6373
反应条件
hydroxylamine hydrochloride; FeOO280 in toluene Condensation; dehydration; 6 h; Heating;
参考文献
Synthetic Communications, , vol. 30, # 15 p. 2785 - 2791
反应条件
T=120°C; Beckmann rearrangement; 2.5 h; Heating;
参考文献
Chandrasekhar, Sosale; Gopalaiah, Kovuru
Tetrahedron Letters, 2003 , vol. 44, # 4 p. 755 - 756
反应条件
hydrogen; palladium on activated charcoal
参考文献
Chemische Berichte, , vol. 107, p. 1221 - 1227
反应条件
1: (i) NH2OH*HCl, Py, (ii) DCC, CuSO4*5H2O, Et3N 2: H2 / Pd-C View Scheme
参考文献
Chemische Berichte, , vol. 107, p. 1221 - 1227
参考文献
Journal of the American Chemical Society, , vol. 70, p. 2293
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C 1.2: 25 °C 2.1: nitric acid / 2 h / 30 °C 3.1: cyclohexene / palladium on carbon / ethanol / Reflux View Scheme
参考文献
Zhao, Xing-Wang; Liu, Dan; Luan, Sheng-Lin; Hu, Guo-Dong; Lv, Jin-Ling; Jing, Yong-Kui; Zhao, Lin-Xiang
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 24 p. 7807 - 7815
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C 1.2: 25 °C 2.1: nitric acid / 2 h / 30 °C View Scheme
参考文献
Zhao, Xing-Wang; Liu, Dan; Luan, Sheng-Lin; Hu, Guo-Dong; Lv, Jin-Ling; Jing, Yong-Kui; Zhao, Lin-Xiang
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 24 p. 7807 - 7815
反应条件
potassium phosphate buffer; lyophilized Zea mays nitrilase ZmNIT2 EC 3.5.5.1 in water T=30°C; pH=7.15; 14 h; Title compound not separated from byproducts;
参考文献
Mukherjee, Chandrani; Zhu, Dunming; Biehl, Edward R.; Parmar, Rajiv R.; Hua, Ling
Tetrahedron, 2006 , vol. 62, # 26 p. 6150 - 6154
反应条件
1.1: potassium carbonate / acetone / 0.08 h / 25 - 30 °C 1.2: 12.5 h / 25 - 30 °C / Reflux 2.1: magnesium / diethyl ether / 0.5 h / Reflux 2.2: 3 h / Reflux 2.3: 6 h / 0 °C / Reflux View Scheme
参考文献
SYMED LABS LIMITED; MOHAN RAO, dodda; KRISHNA REDDY, pingili; VENKAT REDDY, buthukuri
Patent: WO2012/32532 A1, 2012 ;
