反应条件
1.1: K2CO3 / dimethylformamide / 1 h / 20 °C
1.2: dimethylformamide / 20 - 40 °C
2.1: NH4NO3; trifluoroacetic anhydride / CHCl3 / 2 h / Heating
3.1: cyclohexene / Pd/C / ethanol / Heating
4.1: 7 h / Heating
5.1: 99 percent / AcOH / 1 h / 110 °C
6.1: 69 percent / aq. Ce(NH4)2(NO3)6 / CHCl3; acetonitrile / 1 h / Heating
View Scheme
参考文献
Wissner, Allan; Floyd, M. Brawner; Johnson, Bernard D.; Fraser, Heidi; Ingalls, Charles; Nittoli, Thomas; Dushin, Russell G.; Discafani, Carolyn; Nilakantan, Ramaswamy; Marini, Joseph; Ravi, Malini; Cheung, Kinwang; Tan, Xingzhi; Musto, Sylvia; Annable, Tami; Siegel, Marshall M.; Loganzo, Frank
Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7560 - 7581