hydrogenchloride in tetrahydrofuran T=80°C; 2 h;

1: 79 percent / aq. HCl / 5 h / 50 °C 2: CH2Cl2 / 18 h / 20 °C View Scheme

hydrogenchloride T=50°C; 5 h;

1: 80 percent / 1 N HCl / tetrahydrofuran / 2 h / 80 °C 2: 1.) Mg, 2.) CuBr*Me2S, Me2S / 1.) THF, 25 deg, 20 min, 2.) ether, from -78 deg C to 0 deg C, 18 h 3: 89 percent / 0.1 N HCl / tetrahydrofuran / 72 h / 25 °C View Scheme