4-(6-氯-嘧啶-4-基氧基)-哌啶-1-羧酸叔丁酯合成路线 （共 2 条）
反应条件
1: 1-(tert-Butyloxycarbonyl)-4-piperidinol With sodium hydride in tetrahydrofuran
T=60°C; 1 h; Inert atmosphere;
2: 4,6-dichloro-pyrimidine in tetrahydrofuran
T=20°C; 2 h;
参考文献
SCHERING CORPORATION; HARRIS, Joel M.; NEUSTADT, Bernard R.; STAMFORD, Andrew; LIU, Hong
Patent: WO2010/75271 A1, 2010 ;
Location in patent: Page/Page column 36, 37 ;
WO 2010/075271 A1
反应条件
1: 1-(tert-Butyloxycarbonyl)-4-piperidinol With sodium hydride in tetrahydrofuran
T=60°C; 0.666667 h;
2: 4,6-dichloro-pyrimidine in tetrahydrofuran
T=20°C; 0.333333 h;
3: With water in tetrahydrofuran
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2005/121121 A2, 2005 ;
Location in patent: Page/Page column 148 ;
WO 2005/121121 A2
