吡啶 4-(4-甲基苯基)-合成路线 （共 36 条）
反应条件
pyridine; methylammonium sulfite; methylamine in water
T=230°C; 60 h;
参考文献
Gromov; Kurchavov
Russian Chemical Bulletin, 2003 , vol. 52, # 7 p. 1606 - 1609
反应条件
methylammonium sulfite; methylamine in water
T=230°C; Title compound not separated from byproducts;
参考文献
Gromov; Kurchavov
Russian Chemical Bulletin, 2003 , vol. 52, # 7 p. 1606 - 1609
反应条件
1.1: ZnCl2; CoCl2; Bu4NBF4 / acetonitrile; dimethylformamide / Electrochemical reaction
1.2: CuCN; LiCl / 2 h / 0 - 20 °C
2.1: SiO2; O2 / CH2Cl2 / 20 °C
View Scheme
参考文献
Gall, Erwan Le; Gosmini, Corinne; Nedelec, Jean-Yves; Perichon, Jacques
Tetrahedron, 2001 , vol. 57, # 10 p. 1923 - 1927
反应条件
1.1: ZnCl2; CoCl2; Bu4NBF4 / acetonitrile; dimethylformamide / Electrochemical reaction
1.2: CuCN; LiCl / 2 h / 0 - 20 °C
2.1: SiO2; O2 / CH2Cl2 / 20 °C
View Scheme
参考文献
Gall, Erwan Le; Gosmini, Corinne; Nedelec, Jean-Yves; Perichon, Jacques
Tetrahedron, 2001 , vol. 57, # 10 p. 1923 - 1927
反应条件
tricyclohexylphosphine-Au(I); potassium tert-butylate
T=100°C; 24 h; Inert atmosphere;
参考文献
Li, Ming; Hua, Ruimao
Tetrahedron Letters, 2009 , vol. 50, # 13 p. 1478 - 1481
反应条件
potassium acetate; 18-crown-6 ether
1.5 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Beadle, James R.; Korzeniowsky, Stephen H.; Rosenberg, David E.; Garcia-Slanga, Blanche J.; Gokel, George W.
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1594 - 1603
反应条件
1: ammonium chloride; aqueous formaldehyde; concentrated aqueous hydrochloric acid
2: palladium aluminium oxide; nitrobenzene / 160 °C
View Scheme
参考文献
Schmidle et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 1195
反应条件
sulfur; copper(l) iodide; pivaloyl chloride
3.) 200 deg C; Yield given. Multistep reaction;
参考文献
Chambron, Jean-Claude; Sauvage, Jean-Pierre
Tetrahedron, 1987 , vol. 43, # 5 p. 895 - 904
反应条件
hydrogenchloride; sodium nitrite
1.) H2O, 2.) H2O, 40 deg C, 2 h, 80 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Saeki, Seitaro; Kondo, Sachiko; Hayashi, Takaaki; Hamana, Masatomo
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 5 p. 1780 - 1789
参考文献
Furukawa, Naomichi; Tsuruoka, Masayuki; Fujihara, Hisashi
Heterocycles, 1986 , vol. 24, # 12 p. 3337 - 3340
