1,3,4,5-四氢-2H-1-苯并氮杂卓-2-酮合成路线 （共 62 条）
反应条件
1: With sodium azide in toluene T=0 - 10°C; 2: With sulfuric acid in toluene T=5 - 20°C; 54 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2004/69245 A1, 2004 ;
Location in patent: Page/Page column 104 ;
反应条件
P2O5; sodium hydroxide; methanesulfonic acid in water
参考文献
Merck and Co., Inc.
Patent: US5583130 A1, 1996 ;
反应条件
2,4,6-trichloro-1,3,5-triazine in N,N-dimethyl-formamide T=20°C; Beckmann rearrangement; 12 h;
参考文献
De Luca, Lidia; Giacomelli, Giampaolo; Porcheddu, Andrea
Journal of Organic Chemistry, 2002 , vol. 67, # 17 p. 6272 - 6274
反应条件
potassium carbonate; [pentamethylcyclopentadienylRhCl2]2 in acetone T=100°C; 20 h;
参考文献
Fujita, Ken-Ichi; Takahashi, Yoshinori; Owaki, Maki; Yamamoto, Kazunari; Yamaguchi, Ryohei
Organic Letters, 2004 , vol. 6, # 16 p. 2785 - 2788
反应条件
Pd(PCy3)2(H)(H2O)+BF4-; hydrogen; 1,4-di(diphenylphosphino)-butane in toluene T=100°C; P=31028.9 Torr; 48 h; Yield given. Yields of byproduct given;
参考文献
El Ali, Bassam; Okuro, Kazumi; Vasapollo, Giuseppe; Alper, Howard
Journal of the American Chemical Society, 1996 , vol. 118, # 18 p. 4264 - 4270
反应条件
1: With hydrogenchloride; sodium azide in water T=0°C; Schmidt reaction; 0.5 h; 2: With potassium carbonate in water pH=9; Cooling with ice;
参考文献
Meyers, A. I.; Hutchings, Richard H.
Tetrahedron, 1993 , vol. 49, # 9 p. 1807 - 1820
反应条件
phosphoric acid in dichloromethane T=60 - 80°C;
参考文献
Szewczyk, Jerzy Ryszard; Donaldson, Kelly H.
Patent: US2006/3991 A1, 2006 ;
Location in patent: Page/Page column 15 ;
US 20060003991 A1
反应条件
sodium hydroxide in ethanol; water T=90°C; 24 h;
参考文献
Preedasuriyachai, Patcharee; Chavasiri, Warinthorn; Sakurai, Hidehiro
Synlett, 2011 , # 8 art. no. U00511ST, p. 1121 - 1124
反应条件
hydrogen azide; boron trifluoride diethyl etherate in chloroform T=20 - 25°C; 24 h;
参考文献
Sudan, Sangeeta; Gupta, Rajive; Kachroo, P L; Gupta, D K; Bhutani, K K
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1992 , vol. 31, # 9 p. 610 - 612
参考文献
G. D. Searle and Co.
Patent: US5854234 A1, 1998 ;
Title/Abstract Full Text Show Details
G.D. Searle and Co.
Patent: US6046211 A1, 2000 ;
