1,3,4,5-四氢-2H-1-苯并氮杂卓-2-酮合成路线 （共 62 条）
反应条件
sodium hydride in N,N-dimethyl-formamide
3 h;
参考文献
Johnson, Graham P.; Marples, Brian A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3399 - 3406
反应条件
sodium hydride in N,N-dimethyl-formamide
3 h;
参考文献
Johnson, Graham P.; Marples, Brian A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3399 - 3406
反应条件
phosphorus pentachloride in xylene
T=90°C; 0.5 h;
参考文献
Watthey; Stanton; Desai; Babiarz; Finn
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1511 - 1516
反应条件
phosphorus pentachloride in anhydrous xylene; ethanol
参考文献
Ciba-Geigy Corporation
Patent: US4575503 A1, 1986 ;
Title/Abstract Full Text Show Details
Ciba-Geigy Corporation
Patent: US4410520 A1, 1983 ;
Title/Abstract Full Text Show Details
Ciba-Geigy Corporation
Patent: US4473575 A1, 1984 ;
反应条件
1: 90 percent / PCl5 / xylene / 0.5 h / 90 °C
2: 95 percent / H2, sodium acetate / 5percent Pd/C / acetic acid / 0.5 h / 760 Torr / Ambient temperature
3: 90 percent / sodium azide / dimethylsulfoxide / 3 h / 80 °C
4: 96 percent / Bu4NBr, KOH / tetrahydrofuran / 1.5 h / Ambient temperature
5: 93 percent / H2 / 10percent Pd/C / ethanol / 1.5 h / 2280 Torr / Ambient temperature
7: 89 percent / aq. NaOH / methanol / 2 h / Ambient temperature
8: 25 percent / sodium cyanoborohydride / acetic acid; methanol / Ambient temperature
View Scheme
参考文献
Watthey; Stanton; Desai; Babiarz; Finn
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1511 - 1516
反应条件
chlorosulfonic acid in tetrachloromethane
T=70°C; 3 h;
参考文献
Dorogov, Mikhail V.; Ivanovsky, Sergey A.; Khakhina, Maria Y.; Kravchenko, Dmitry V.; Tkachenko, Sergey E.; Ivachtchenko, Alexandre V.
Synthetic Communications, 2006 , vol. 36, # 23 p. 3525 - 3535
反应条件
1: lithium alanate; diethyl ether
2: hydroxylamine hydrochloride; sodium sulfate; water / Reagens 4: Salzsaeure; und Erwaermen des Reaktionsprodukts mit konz.Schwefelsaeure
View Scheme
参考文献
Astill; Boekelheide
Journal of the American Chemical Society, 1955 , vol. 77, p. 4079,4081
反应条件
1: 70 percent / HNO3; H2SO4 / 0 - 5 °C
2: 85 percent / BH3 / tetrahydrofuran / 60 °C
View Scheme
参考文献
Johnson, Paul D.; Aristoff, Paul A.; Zurenko, Gary E.; Schaadt, Ronda D.; Yagi, Betty H.; Ford, Charles W.; Hamel, Judith C.; Stapert, Douglas; Moerman, Judy K.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4197 - 4200
反应条件
1.1: sulfuric acid; nitric acid / 0.25 h / 0 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: 10 palladium on activated carbon; hydrazine hydrate / ethanol / 60 °C
View Scheme
参考文献
SANOFI; CARRY, Jean-Christophe; CHATREAUX, Fabienne; DEPRETS, Stéphanie; DUCLOS, Olivier; LEROY, Vincent; MALLART, Sergio; MELON-MANGUER, Dominique; MENDEZ-PEREZ, Maria; VERGNE, Fabrice
Patent: WO2013/150036 A1, 2013 ;
反应条件
1: With sulfuric acid; bromine in acetic acid
T=20°C; 12 h;
2: With ammonia in water
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/113432 A2, 2006 ;
Location in patent: Page/Page column 51 ;
