potassium hydroxide in ethylene glycol
0.5 h; Heating;
参考文献
Carroll, F. Ivy; Blough, Bruce E.; Huang, Xiaodong; Nie, Zhe; Mascarella, S. Wayne; Deschamps, Jeffrey; Navarro, Hernan A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 15 p. 4589 - 4594
1: With sodium methylate; N-benzyl-trimethylammonium hydroxide in 1,4-dioxane
T=30°C; 17 h;
2: With sodium hydroxide in 1,4-dioxane; water
3: With hydrogenchloride in water
参考文献
Adchemco Corporation
Patent: EP1215192 A2, 2002 ;
Location in patent: Example 5 ;
1: 55 percent / Triton B / dioxane / 3 h / 20 °C
2: 28 percent / aq. KOH / ethane-1,2-diol / 0.5 h / Heating
View Scheme
参考文献
Carroll, F. Ivy; Blough, Bruce E.; Huang, Xiaodong; Nie, Zhe; Mascarella, S. Wayne; Deschamps, Jeffrey; Navarro, Hernan A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 15 p. 4589 - 4594
