6-(2-(二甲氧基甲基)-5-(6-甲基吡啶-2-基)-1H-咪唑-4-基)喹噁啉合成路线 （共 4 条）
反应条件
in methanol; water
T=20°C; 3 h;
参考文献
Kim, Dae-Kee; Jang, Yoojeung; Ho, Soon Lee; Park, Hyun-Ju; Yoo, Jakyung
Journal of Medicinal Chemistry, 2007 , vol. 50, # 13 p. 3143 - 3147
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -60 °C
1.2: Et2AlCl / tetrahydrofuran; hexane / -60 - 20 °C
1.3: 65 percent / tetrahydrofuran; hexane / 0.33 h / -60 °C
2.1: 66 percent / DMSO; aq. HBr / 2 h / 60 - 70 °C
3.1: 83 percent / various solvent(s); methanol; H2O / 3 h / 20 °C
View Scheme
参考文献
Kim, Dae-Kee; Jang, Yoojeung; Ho, Soon Lee; Park, Hyun-Ju; Yoo, Jakyung
Journal of Medicinal Chemistry, 2007 , vol. 50, # 13 p. 3143 - 3147
反应条件
1: 66 percent / DMSO; aq. HBr / 2 h / 60 - 70 °C
2: 83 percent / various solvent(s); methanol; H2O / 3 h / 20 °C
View Scheme
参考文献
Kim, Dae-Kee; Jang, Yoojeung; Ho, Soon Lee; Park, Hyun-Ju; Yoo, Jakyung
Journal of Medicinal Chemistry, 2007 , vol. 50, # 13 p. 3143 - 3147
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -60 °C
1.2: Et2AlCl / tetrahydrofuran; hexane / -60 - 20 °C
1.3: 65 percent / tetrahydrofuran; hexane / 0.33 h / -60 °C
2.1: 66 percent / DMSO; aq. HBr / 2 h / 60 - 70 °C
3.1: 83 percent / various solvent(s); methanol; H2O / 3 h / 20 °C
View Scheme
参考文献
Kim, Dae-Kee; Jang, Yoojeung; Ho, Soon Lee; Park, Hyun-Ju; Yoo, Jakyung
Journal of Medicinal Chemistry, 2007 , vol. 50, # 13 p. 3143 - 3147
