5-氟-3-亚甲基-1,3-二氢-2H-吲哚-2-酮合成路线 （共 5 条）
反应条件
1: With boron trifluoride diethyl etherate in dichloromethane
T=-78°C; 2 h;
2: T=0°C; 1 h;
参考文献
Rossiter, Sharon
Tetrahedron Letters, 2002 , vol. 43, # 26 p. 4671 - 4673
反应条件
1.1: diethyl ether / 0.25 h / -78 °C
1.2: 56 percent / 18 h / 20 °C
2.1: boron trifluoride diethyl etherate / CH2Cl2 / 2 h / -78 °C
2.2: 58 percent / 1 h / 0 °C
View Scheme
参考文献
Rossiter, Sharon
Tetrahedron Letters, 2002 , vol. 43, # 26 p. 4671 - 4673
反应条件
1.1: CuBr2 / ethyl acetate / 80 °C
2.1: water / methanol / 2 h / Heating
3.1: diethyl ether / 0.25 h / -78 °C
3.2: 56 percent / 18 h / 20 °C
4.1: boron trifluoride diethyl etherate / CH2Cl2 / 2 h / -78 °C
4.2: 58 percent / 1 h / 0 °C
View Scheme
参考文献
Rossiter, Sharon
Tetrahedron Letters, 2002 , vol. 43, # 26 p. 4671 - 4673
反应条件
1.1: water / methanol / 2 h / Heating
2.1: diethyl ether / 0.25 h / -78 °C
2.2: 56 percent / 18 h / 20 °C
3.1: boron trifluoride diethyl etherate / CH2Cl2 / 2 h / -78 °C
3.2: 58 percent / 1 h / 0 °C
View Scheme
参考文献
Rossiter, Sharon
Tetrahedron Letters, 2002 , vol. 43, # 26 p. 4671 - 4673
反应条件
horseradish peroxidase in ethanol; water
T=37°C; 2 h; Kinetics;
参考文献
Folkes, Lisa K.; Rossiter, Sharon; Wardman, Peter
Chemical Research in Toxicology, 2002 , vol. 15, # 6 p. 877 - 882
