1-(4-碘-1H-吡咯并[2,3-b]吡啶)-乙酮合成路线 （共 9 条）
反应条件
triethylamine; tetrakis(triphenylphosphine) palladium(0) T=60°C; 12 h;
参考文献
Allegretti, Marcello; Arcadi, Antonio; Marinelli, Fabio; Nicolini, Luca
Synlett, 2001 , # 5 p. 609 - 612
反应条件
sodium methylate in methanol; ethanol 1 h; Reflux;
参考文献
Riken; TagCyx Biotechnologies
Patent: EP2487180 A1, 2012 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With sodium iodide in acetonitrile
T=20 - 85°C; 12 h;
2: With sodium carbonate; sodium hydrogensulfite in water
T=20°C; 0.25 h;
参考文献
Riken; TagCyx Biotechnologies
Patent: EP2487180 A1, 2012 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With sodium iodide in acetonitrile
Heating / reflux;
2: With sodium carbonate; sodium hydrogensulfite in acetonitrile
T=20°C; 0.25 h;
参考文献
AMGEN INC.
Patent: WO2006/12374 A1, 2006 ;
Location in patent: Page/Page column 215 ;
WO 2006/012374 A1
反应条件
sodium hydrogen sulphate; sodium carbonate; sodium iodide in acetonitrile
参考文献
Amgen Inc.
Patent: US6878714 B2, 2005 ;
US 6878714 B2
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 4 h / 0 - 20 °C
1.2: 2 h / 0 - 20 °C / pH 10
1.3: 0 - 75 °C
2.1: sodium iodide / acetonitrile / 12 h / 20 - 85 °C
2.2: 0.25 h / 20 °C
View Scheme
参考文献
Riken; TagCyx Biotechnologies
Patent: EP2487180 A1, 2012 ;
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; copper (I) cyanide; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane
2 h; Heating / reflux;
参考文献
Amgen Inc.
Patent: US2003/225106 A1, 2003 ;
Location in patent: Page 95 ;
反应条件
Pd2dba3; CuCN in 1,4-dioxane; ethyl acetate
参考文献
Amgen Inc.
Patent: US6878714 B2, 2005 ;
US 6878714 B2
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane
2 h; Heating / reflux;
参考文献
AMGEN INC.
Patent: WO2006/12374 A1, 2006 ;
Location in patent: Page/Page column 215 ;
WO 2006/012374 A1
