4-(5-氨基-1H-1,2,4-噻唑-3-基氨基)-N-甲基苯磺酰胺合成路线 （共 3 条）
反应条件
hydrazine in ethanol T=65°C; P=760.051 Torr; 3 h; Inert atmosphere;
参考文献
WO2014/6066 A1, ;
Paragraph 0204 ;
反应条件
1.1: calcium carbonate / dichloromethane; water / 0 - 20 °C / 760.05 Torr / |Inert atmosphere 2.1: sodium methylate / 0.25 h / 20 °C / 760.05 Torr / |Inert atmosphere 2.2: 1 h / 760.05 Torr / |Inert atmosphere 2.3: 20 °C / 760.05 Torr / |Inert atmosphere 3.1: hydrazine / ethanol / 3 h / 65 °C / 760.05 Torr / |Inert atmosphere View Scheme
反应条件
1.1: sodium methylate / 0.25 h / 20 °C / 760.05 Torr / |Inert atmosphere 1.2: 1 h / 760.05 Torr / |Inert atmosphere 1.3: 20 °C / 760.05 Torr / |Inert atmosphere 2.1: hydrazine / ethanol / 3 h / 65 °C / 760.05 Torr / |Inert atmosphere View Scheme
