3-氯-4-(3-氟苄氧基)硝基苯合成路线 （共 10 条）
反应条件
potassium carbonate in acetone T=30°C; 16 h;
参考文献
CURIS, INC.
Patent: WO2008/33747 A2, 2008 ;
Location in patent: Page/Page column 172 ;
反应条件
potassium hydroxide in acetonitrile T=35 - 40°C; 18 h;
参考文献
Chew, Warren; Papamichelakis, Maria
Patent: US2006/270669 A1, 2006 ;
Location in patent: Page/Page column 19-20 ;
反应条件
1: 3-fluorobenzyl alcohol With sodium hydride in DMF (N,N-dimethyl-formamide) T=0°C; 0.25 h; 2: 1-chloro-2-fluoro-5-nitrobenzene in DMF (N,N-dimethyl-formamide) 4.33333 h;
参考文献
Wallace, Eli; Topolov, George; Zhao, Qian; Lyssikatos, Joseph P.
Patent: US2005/101617 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
1: 2-chloro-4-nitrophenol With potassium carbonate in N,N-dimethyl-formamide T=23 - 42°C; 2: 3-fluoro-1-bromomethylbenzene in N,N-dimethyl-formamide T=80 - 95°C; 5 h;
参考文献
Concert Pharmaceuticals Inc.
Patent: US2008/51422 A1, 2008 ;
Location in patent: Page/Page column 13-14 ;
反应条件
potassium hydroxide; Aliquatreg; 336 in water; toluene T=60°C;
参考文献
BAYER HEALTHCARE AG
Patent: WO2009/33581 A1, 2009 ;
Location in patent: Page/Page column 58-59 ;
反应条件
1: H2 / Pt/C / ethanol; tetrahydrofuran 2: propan-2-ol / 70 °C 3: Pd(OAc)2; PPh3; Et3N / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691
反应条件
1: 2-chloro-1-(3-fluorobenzyloxy)-4-nitrobenzene With water; iron; ammonium chloride in ethanol 5 h; Reflux; 2: 4-chloro-6-iodo quinazoline in isopropyl alcohol 0.5 h; Reflux;
参考文献
WO2010/17387 A2, ;
Page/Page column 21-22 ;
反应条件
1: H2 / Pt/C / ethanol; tetrahydrofuran 2: propan-2-ol / 70 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691
参考文献
Lackey, Karen Elizabeth; Spector, Neil; Wood lll, Edgar Raymond; Xia, Wenle
Patent: US2004/53946 A1, 2004 ;
反应条件
1: H2 / Pt/C / ethanol; tetrahydrofuran 2: propan-2-ol / 70 °C 3: Pd(OAc)2; PPh3; Et3N / dimethylformamide 4: Na(OAc)3BH; HOAc / CH2Cl2 View Scheme
参考文献
Petrov, Kimberly G.; Zhang, Yue-Mei; Carter, Malcolm; Cockerill, G. Stuart; Dickerson, Scott; Gauthier, Cassandra A.; Guo, Yu; Mook Jr., Robert A.; Rusnak, David W.; Walker, Ann L.; Wood, Edgar R.; Lackey, Karen E.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4686 - 4691
