(2,3-二氢-[1,4]二噁英o[2,3-c]吡啶-7-基)甲醇合成路线 （共 12 条）
反应条件
1: 2-(hydroxymethyl)-5-[(phenylmethyl)oxy]-4-oxo-1,4-dihydropyridine With sodium hydroxide; hydrogen; palladium 10 on activated carbon in water 4 h; 2: ethylene dibromide With potassium carbonate in N,N-dimethyl-formamide T=85°C;
参考文献
WO2006/2047 A2, ;
Page/Page column 94 ;
反应条件
1: With sodium hydroxide; hydrogen; palladium 10 on activated carbon in water 4 h; 2: With potassium carbonate; ethylene dibromide in DMF (N,N-dimethyl-formamide) T=85°C;
参考文献
WO2004/2992 A1, ;
Page 89 ;
反应条件
1: 2-(hydroxymethyl)-5-[(phenylmethyl)oxy]-4-oxo-1,4-dihydropyridine With sodium hydroxide; hydrogen; palladium 10 on activated carbon 4 h; 2: ethylene dibromide With potassium carbonate in N,N-dimethyl-formamide T=85°C;
参考文献
WO2006/81264 A1, ;
Page/Page column 26 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=85°C;
参考文献
WO2006/81289 A2, ;
Page/Page column 24 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-30 - 20°C; 2 h; 2: With water in tetrahydrofuran
参考文献
WO2003/87098 A1, ;
Page/Page column 61 ;
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=85°C;
参考文献
WO2004/2490 A2, ;
Page/Page column 54 ;
反应条件
sodium tetrahydroborate in ethanol T=20°C; 2 h;
参考文献
WO2004/87145 A2, ;
Page/Page column 62 ;
反应条件
ammonia in water T=20 - 85°C;
参考文献
EP2221309 A1, ;
Page/Page column 19 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=100°C;
参考文献
WO2006/21448 A1, ;
Page/Page column 70 ;
反应条件
1: methanol / 5 h / 100 °C 2: ammonium hydroxide / 16 h / 90 °C / |Sealed tube 3: palladium 10 on activated carbon; hydrogen; sodium hydroxide / water / 16 h / 20 °C / |Inert atmosphere 4: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C View Scheme
