3-氧代-3,4-二氢-2H-吡啶并[3,2-b][1,4]噻嗪-6-羧酸合成路线 （共 5 条）
反应条件
Oxonereg; in N,N-dimethyl-formamide
T=20°C; 1.5 h; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/17326 A1, 2006 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: With sodium hydroxide; water in 1,4-dioxane
2 h;
2: With hydrogenchloride in 1,4-dioxane; water
pH=4;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/81178 A2, 2006 ;
Location in patent: Page/Page column 21 ;
反应条件
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.42 h / 0 °C
1.2: 4 h
2.1: water; sodium hydroxide / 1,4-dioxane / 16 h / 23 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BURKE, Michael J.; MCKIBBEN, Bryan; TSCHANTZ, Matt Aaron
Patent: WO2013/191984 A1, 2013 ;
反应条件
1: With triethylamine; isobutyl chloroformate in tetrahydrofuran
T=-10°C; 0.333333 h;
2: With sodium tetrahydroborate in tetrahydrofuran; water
0.5 h;
3: With hydrogenchloride in tetrahydrofuran; water
pH=7;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/118130 A2, 2007 ;
Location in patent: Page/Page column 32 ;
反应条件
1: With triethylamine in tetrahydrofuran
T=-10 - 0°C; 0.333333 h;
2: With sodium tetrahydroborate in tetrahydrofuran; water
pH=7; 0.5 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/81178 A2, 2006 ;
Location in patent: Page/Page column 21 ;
