6-(羟基甲基)-2H-吡啶并[3,2-b][1,4]噻嗪-3(4h)-酮合成路线 (共 4 条)
反应条件
1: With triethylamine; isobutyl chloroformate in tetrahydrofuran
T=-10°C; 0.333333 h;
2: With sodium tetrahydroborate in tetrahydrofuran; water
0.5 h;
3: With hydrogenchloride in tetrahydrofuran; water
pH=7;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/118130 A2, 2007 ;
Location in patent: Page/Page column 32 ;
反应条件
1: With triethylamine in tetrahydrofuran
T=-10 - 0°C; 0.333333 h;
2: With sodium tetrahydroborate in tetrahydrofuran; water
pH=7; 0.5 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/81178 A2, 2006 ;
Location in patent: Page/Page column 21 ;
反应条件
1: With lithium triethylborohydride in tetrahydrofuran
T=5 - 10°C; 1.16667 h;
2: With dihydrogen peroxide; acetic acid in tetrahydrofuran; methanol
T=10 - 37°C;
参考文献
ACTELION PHARMACEUTICALS LTD.
Patent: US2011/39836 A1, 2011 ;
Location in patent: Page/Page column 16-17 ;
反应条件
manganese(IV) oxide in tetrahydrofuran; dichloromethane
T=20°C; 37 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/81178 A2, 2006 ;
Location in patent: Page/Page column 21-22 ;