2-氨基-5-溴-3-(羟甲基)吡啶氢溴酸盐合成路线 （共 5 条）
反应条件
bromine; acetic acid T=20 - 35°C; 3 h;
参考文献
WO2013/80222 A1, ;
Page/Page column 29 ;
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / |Reflux 2: acetic acid; bromine / 3 h / 20 - 35 °C View Scheme
反应条件
1: hydrogen bromide / water / 16 h / |Reflux 2: sodium methylate / methanol / 16 h / 20 - 35 °C View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana
Patent: WO2013/80222 A1, 2013 ;
反应条件
1.1: hydrogen bromide / water / 16 h / |Reflux 2.1: sodium methylate / methanol / 16 h / 20 - 35 °C 3.1: sodium hydroxide / methanol / 4 h / |Reflux 3.2: 16 h / |Reflux View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana
Patent: WO2013/80222 A1, 2013 ;
反应条件
1: hydrogen bromide / water / 16 h / |Reflux
2: triethylamine / N,N-dimethyl-formamide / 5 h / 20 - 35 °C
3: sodium hydride / dimethyl sulfoxide / 5 h / 20 - 35 °C
View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana
Patent: WO2013/80222 A1, 2013 ;
