1: 1-cyano-3-iodobenzene With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=-20°C; Inert atmosphere; 2: With lithium chlorozincate in tetrahydrofuran T=25°C; Inert atmosphere; 3: 4-bromo-aniline With bis(dibenzylideneacetone)-palladium(0); dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in tetrahydrofuran T=25°C; Negishi cross-coupling reaction; 0.166667 h; Inert atmosphere;

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate in ethylene glycol dimethyl ether T=100°C; Suzuki coupling; 5 h;

tetrakis(triphenylphosphine) palladium(0); caesium carbonate in water; toluene; butan-1-ol T=80°C; Suzuki reaction;