1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; 48.5 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2006/34440 A2, 2006 ;
Location in patent: Page/Page column 48 ;
WO 2006/034440 A2
