2-氟-5-(4-甲氧基苯基)吡啶合成路线 （共 12 条）
反应条件
potassium carbonate in ethanol; water
T=90°C; Suzuki Coupling; 1 h; Microwave irradiation;
参考文献
Bratt, Emma; Verho, Oscar; Johansson, Magnus J; Baeckvall, Jan-Erling
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 3946 - 3954
反应条件
potassium carbonate in ethanol; water
T=90°C; Suzuki Coupling; 0.25 h; Microwave irradiation;
参考文献
Bratt, Emma; Verho, Oscar; Johansson, Magnus J; Baeckvall, Jan-Erling
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 3946 - 3954
反应条件
potassium carbonate in ethanol; water
T=90°C; Suzuki Coupling; 0.5 h; Microwave irradiation; Concentration;
参考文献
Bratt, Emma; Verho, Oscar; Johansson, Magnus J; Baeckvall, Jan-Erling
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 3946 - 3954
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=65°C;
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in 1,4-dioxane; water
Suzuki coupling; 14 h; Inert atmosphereReflux;
参考文献
Siddle, Jamie S.; Batsanov, Andrei S.; Caldwell, Stuart T.; Cooke, Graeme; Bryce, Martin R.
Tetrahedron, 2010 , vol. 66, # 32 p. 6138 - 6149
反应条件
1: 75 percent / periodic acid dihydrate; iodine; sulfuric acid / acetic acid; H2O / 4 h / 80 °C
2: 45 percent / NaNO2; fluoroboric acid / H2O / -5 - 45 °C
3: 25 percent / nBuLi; triisopropylborate / diethyl ether / -78 - 20 °C
4: Pd(PPh3)4; NaHCO3 / 1,2-dimethoxy-ethane / 80 °C
View Scheme
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
反应条件
1: 45 percent / NaNO2; fluoroboric acid / H2O / -5 - 45 °C
2: 25 percent / nBuLi; triisopropylborate / diethyl ether / -78 - 20 °C
3: Pd(PPh3)4; NaHCO3 / 1,2-dimethoxy-ethane / 80 °C
View Scheme
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
反应条件
1.1: nBuLi; triisopropylborate / diethyl ether / -78 - 20 °C
1.2: 65 percent / acetic acid / diethyl ether
2.1: 47 percent / Pd(PPh3)4; aq. K3PO4 / dimethylformamide / 65 °C
View Scheme
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
反应条件
1: 25 percent / nBuLi; triisopropylborate / diethyl ether / -78 - 20 °C
2: Pd(PPh3)4; NaHCO3 / 1,2-dimethoxy-ethane / 80 °C
View Scheme
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
反应条件
1.1: 100 percent / aq. HCl / dioxane / 24 h / Heating
2.1: LiH / dimethylformamide / 1.5 h / 50 °C
2.2: 68 percent / dimethylformamide / 16 h
View Scheme
参考文献
McCarthy, Anna R.; Hartmann, Rolf W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3603 - 3607
