2-氯-5-(4,4,5,5-四甲基-1,3,2-二氧硼烷)吡啶合成路线 （共 11 条）
反应条件
1: 5-Bromo-2-chloropyridine With n-butyllithium; tri-isopropoxy-borane in diethyl ether T=-78 - 20°C; 2: 2,3-dimethylbutane-2,3-diol With acetic acid in diethyl ether
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
反应条件
magnesium sulfate in diethyl ether T=20°C; 16 h;
参考文献
Watson, Charlotte G.; Aggarwal, Varinder K.
Organic Letters, 2013 , vol. 15, # 6 p. 1346 - 1349
反应条件
1: 3-chloro-6-chloropyridine With n-butyllithium; tri-isopropoxy-borane in diethyl ether T=-78 - 20°C; 2: 2,3-dimethylbutane-2,3-diol With acetic acid in diethyl ether
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
反应条件
1: 2-Chloro-5-iodopyridine With n-butyllithium; tri-isopropoxy-borane in diethyl ether T=-78 - 20°C; 2: 2,3-dimethylbutane-2,3-diol With acetic acid in diethyl ether
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
反应条件
1.1: 75 percent / periodic acid dihydrate; iodine; sulfuric acid / acetic acid; H2O / 4 h / 80 °C 2.1: 56 percent / HCl; sodium nitrite; copper(I) chloride / H2O / -5 - 20 °C 3.1: nBuLi; triisopropylborate / diethyl ether / -78 - 20 °C 3.2: 20 percent / acetic acid / diethyl ether View Scheme
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
反应条件
1.1: 55 percent / HCl; NaNO2; copper(I) chloride / H2O / -5 - 20 °C 2.1: nBuLi; triisopropylborate / diethyl ether / -78 - 20 °C 2.2: 71 percent / acetic acid / diethyl ether View Scheme
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
反应条件
1.1: 56 percent / HCl; sodium nitrite; copper(I) chloride / H2O / -5 - 20 °C 2.1: nBuLi; triisopropylborate / diethyl ether / -78 - 20 °C 2.2: 20 percent / acetic acid / diethyl ether View Scheme
参考文献
Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain
Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
反应条件
dihydrogen peroxide in dichloromethane; water T=20°C; 20 h;
参考文献
Voisin, Anne Sophie; Bouillon, Alexandre; Lancelot, Jean-Charles; Rault, Sylvain
Tetrahedron, 2005 , vol. 61, # 6 p. 1417 - 1421
反应条件
1: With phenyllithium in tetrahydrofuran T=-78 - 20°C; 3 h; Inert atmosphere; 2: With sodium hydroxide in tetrahydrofuran; water T=0°C; 1.5 h;
参考文献
Emerson, Christopher R.; Zakharov, Lev N.; Blakemore, Paul R.
Chemistry - A European Journal, 2013 , vol. 19, # 48 p. 16342 - 16356
反应条件
zinc(II) chloride in tetrahydrofuran; toluene; pentane T=-78 - 20°C; 22 h; Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 19, # 48 p. 16342 - 16356
