2,3-二氢-1,4-苯并二烷-5-羧酸合成路线 （共 14 条）
反应条件
1: With aminosulfonic acid in water; acetone T=0 - 5°C; 0.333333 h; 2: With sodium chlorite in water; acetone T=22 - 26°C; 18 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; DESHMUKH, Sanjay; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/153535 A1, 2013 ;
Location in patent: Page/Page column 63 ;
反应条件
potassium hydroxide unter Ausschluss von Sauerstoff;
参考文献
Adir et Compagnie
Patent: US5919814 A1, 1999 ;
反应条件
1: sulfuric acid / 10 h / Reflux 2: potassium carbonate / N,N-dimethyl-formamide / 5 h / Reflux 3: sodium hydroxide / water / 3 h / Reflux View Scheme
参考文献
Duan, Yong-Tao; Yao, Yong-Fang; Huang, Wei; Makawana, Jigar A.; Teraiya, Shashikant B.; Thumar, Nilesh J.; Tang, Dan-Jie; Tao, Xiang-Xiang; Wang, Zhong-Chang; Jiang, Ai-Qin; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 2947 - 2954
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 - 70 °C 1.2: 16 h / 80 - 90 °C 2.1: aminosulfonic acid / water; acetone / 0.33 h / 0 - 5 °C 2.2: 18 h / 22 - 26 °C View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; DESHMUKH, Sanjay; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/153535 A1, 2013 ;
反应条件
1: thionyl chloride 2: benzene; aqueous ammonia View Scheme
参考文献
Fuson; Gaertner; Chadwick
Journal of Organic Chemistry, 1948 , vol. 13, p. 489,493
参考文献
Adir et Compagnie
Patent: US5332735 A1, 1994 ;
反应条件
1.1: triethylamine / water; acetone / 0 °C 2.1: sodium azide / water; acetone 2.2: Heating 3.1: hydrogenchloride / water / Reflux 4.1: chlorobenzene / Reflux View Scheme
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen
Patent: WO2012/3418 A2, 2012 ;
WO 2012/003418 A2
反应条件
1: bromine; acetic acid / 2 h / 120 °C 2: sulfuric acid; nitric acid / acetic acid / 1 h / 37 - 50 °C 3: sodium carbonate; palladium on activated charcoal; hydrogen / water / 50 °C / 30003 Torr / |Autoclave View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BAKER-GLENN, Charles; BURDICK, Daniel Jon; CHAMBERS, Mark; CHAN, Bryan K.; CHEN, Huifen; ESTRADA, Anthony; GUNZNER-TOSTE, Janet; SHORE, Daniel; SWEENEY, Zachary; WANG, Shumei; ZHAO, Guiling
Patent: WO2013/79494 A1, 2013 ;
反应条件
1.1: triethylamine / water; acetone / 0 °C 2.1: sodium azide / water; acetone 2.2: Heating 3.1: hydrogenchloride / water / Reflux View Scheme
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen
Patent: WO2012/3418 A2, 2012 ;
WO 2012/003418 A2
反应条件
1: thionyl chloride 2: benzene; aqueous ammonia 3: thionyl chloride View Scheme
参考文献
Fuson; Gaertner; Chadwick
Journal of Organic Chemistry, 1948 , vol. 13, p. 489,493
