5-(1,1,1,3,3,3-六氟-2-羟基丙烷-2-基)-4,5-二氢异噁唑-3-羧酸合成路线 （共 2 条）
反应条件
sodium hydroxide in tetrahydrofuran
T=20°C; 1 h;
参考文献
Cheng, Jie-Fei; Huang, Yujin; Penuliar, Richard; Nishimoto, Masahiro; Liu, Larry; Arrhenius, Thomas; Yang, Guang; O'Leary, Eoin; Barbosa, Miguel; Barr, Rick; Dyck, Jason R. B.; Lopaschuk, Gary D.; Nadzan, Alex M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4055 - 4058
反应条件
1: 3.06 g / Et3N / tetrahydrofuran / 68 h / 20 °C
2: 98 percent / aq. NaOH / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Cheng, Jie-Fei; Huang, Yujin; Penuliar, Richard; Nishimoto, Masahiro; Liu, Larry; Arrhenius, Thomas; Yang, Guang; O'Leary, Eoin; Barbosa, Miguel; Barr, Rick; Dyck, Jason R. B.; Lopaschuk, Gary D.; Nadzan, Alex M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4055 - 4058
