5H-二苯并[a,c]环庚烯-5-酮合成路线 （共 15 条）
反应条件
1: With toluene-4-sulfonic acid in ethanol; water
T=20°C; 0.0166667 h; Inert atmosphere;
2: With sodium hydroxide in ethanol; water
T=70°C; 0.166667 h;
参考文献
Young, Lok Choi; Yu, Chan-Mo; Bum, Tae Kim; Heo, Jung-Nyoung
Journal of Organic Chemistry, 2009 , vol. 74, # 10 p. 3948 - 3951
反应条件
lithium chloride in N,N-dimethyl-formamide
参考文献
Seganish, W. Michael; DeShong, Philip
Organic Letters, 2006 , vol. 8, # 18 p. 3951 - 3954
反应条件
1: H2 / Pd/C / ethyl acetate
2: 79 percent / LiCl / dimethylformamide
View Scheme
参考文献
Seganish, W. Michael; DeShong, Philip
Organic Letters, 2006 , vol. 8, # 18 p. 3951 - 3954
反应条件
1: (i) (heating), (ii) aq. NaHCO3, MeCN
2: MnO2 / CH2Cl2
3: H2 / Pd-C / ethyl acetate; acetic acid
4: LiCl / dimethylformamide / Heating
View Scheme
参考文献
Coburn,T.T.; Jones,W.M.
Journal of the American Chemical Society, 1974 , vol. 96, # 16 p. 5218 - 5227
反应条件
1: MnO2 / CH2Cl2
2: H2 / Pd-C / ethyl acetate; acetic acid
3: LiCl / dimethylformamide / Heating
View Scheme
参考文献
Coburn,T.T.; Jones,W.M.
Journal of the American Chemical Society, 1974 , vol. 96, # 16 p. 5218 - 5227
反应条件
tetrakis(triphenylphosphine) palladium(0); caesium carbonate in ethanol; toluene
T=150°C; 0.166667 h; Microwave irradiationInert atmosphere;
参考文献
Young, Lok Choi; Yu, Chan-Mo; Bum, Tae Kim; Heo, Jung-Nyoung
Journal of Organic Chemistry, 2009 , vol. 74, # 10 p. 3948 - 3951
反应条件
1: 92 percent / benzyl(triethyl)ammonium chloride; NaOH / 5 h / 20 °C
2: 95 percent / HCl / tetrahydrofuran; propan-2-ol / 5 h / 100 °C
3: H2 / Pd/C / ethyl acetate
4: 79 percent / LiCl / dimethylformamide
View Scheme
参考文献
Seganish, W. Michael; DeShong, Philip
Organic Letters, 2006 , vol. 8, # 18 p. 3951 - 3954
反应条件
1: 95 percent / HCl / tetrahydrofuran; propan-2-ol / 5 h / 100 °C
2: H2 / Pd/C / ethyl acetate
3: 79 percent / LiCl / dimethylformamide
View Scheme
参考文献
Seganish, W. Michael; DeShong, Philip
Organic Letters, 2006 , vol. 8, # 18 p. 3951 - 3954
反应条件
1: 89 percent / Hunig's base / CH2Cl2 / 12 h / 20 °C
2: 92 percent / benzyl(triethyl)ammonium chloride; NaOH / 5 h / 20 °C
3: 95 percent / HCl / tetrahydrofuran; propan-2-ol / 5 h / 100 °C
4: H2 / Pd/C / ethyl acetate
5: 79 percent / LiCl / dimethylformamide
View Scheme
参考文献
Seganish, W. Michael; DeShong, Philip
Organic Letters, 2006 , vol. 8, # 18 p. 3951 - 3954
反应条件
lead(IV) acetate; benzene
Behandeln des in Methanol geloesten Reaktionsprodukts mit wss. NaOH unter Stickstoff, anfangs unter Erwaermen;
参考文献
Naville,G. et al.
Helvetica Chimica Acta, 1960 , vol. 43, p. 1221 - 1243
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Cook et al.
Journal of the Chemical Society, 1951 , p. 1397,1401
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Buchanan et al.
Nature (London, United Kingdom), 1948 , vol. 162, p. 692
