2-(4-氯苯基)-2-羟基丙酸合成路线 （共 9 条）
反应条件
hydrogen iodide in water T=90°C; 18 h;
参考文献
Aramini, Andrea; Sablone, Manolo R.; Bianchini, Gianluca; Amore, Alessia; Fani, Michela; Perrone, Plinio; Dolce, Alberto; Allegretti, Marcello
Tetrahedron, 2009 , vol. 65, # 10 p. 2015 - 2021
反应条件
sodium hypochlorite; ORMOSIL-entrapped TEMPO; sodium hydrogencarbonate in acetonitrile
T=0°C; pH=9.1;
参考文献
Gancitano, Pamela; Ciriminna, Rosaria; Testa, Maria Luisa; Fidalgo, Alexandra; Ilharco, Laura M.; Pagliaro, Mario
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 13 p. 2389 - 2392
反应条件
lithium aluminium tetrahydride; titanium tetrachloride in tetrahydrofuran
T=-5°C; 0.5 h;
参考文献
Garcia, Mariano; Del Campo, Carmen; Sinisterra, Jose V.; Llama, Emilio F.
Tetrahedron Letters, 1993 , vol. 34, # 49 p. 7973 - 7974
反应条件
in tetrahydrofuran; water
参考文献
Syngenta Participations AG
Patent: US6469005 B1, 2002 ;
反应条件
hydrogenchloride; water in 1,4-dioxane
Reflux;
参考文献
Aramini, Andrea; Sablone, Manolo R.; Bianchini, Gianluca; Amore, Alessia; Fani, Michela; Perrone, Plinio; Dolce, Alberto; Allegretti, Marcello
Tetrahedron, 2009 , vol. 65, # 10 p. 2015 - 2021
反应条件
potassium tert-butylate in hexane
0.5 h; Ambient temperature;
参考文献
Garcia; Del Campo; Llama; Sanchez-Montero; Sinisterra
Tetrahedron, 1993 , vol. 49, # 37 p. 8433 - 8440
反应条件
in diethyl ether
1 h; Heating;
参考文献
Geffken; Frobose
Pharmazie, 1994 , vol. 49, # 12 p. 889 - 893
反应条件
platinum on activated charcoal; water; oxygen; sodium hydrogencarbonate
T=70°C;
参考文献
Weaver, Jimmie D.; Ka, Being J.; Morris, David K.; Thompson, Ward; Tunge, Jon A.
Journal of the American Chemical Society, 2010 , vol. 132, # 35 p. 12179 - 12181
参考文献
Skerrett; Woodcock
Journal of the Chemical Society, 1952 , p. 2806,2808
