4'-氨基-联苯-3-羧酸合成路线 （共 13 条）
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide); water
T=80°C; 15 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2003/97641 A2, 2003 ;
Location in patent: Page/Page column 70 ;
WO 03/097641 A2
反应条件
sodium hydroxide; dihydrogen peroxide
T=50°C; 0.5 h;
参考文献
Gerard, Anne-Laure; Lisowski, Vincent; Rault, Sylvain
Tetrahedron, 2005 , vol. 61, # 25 p. 6082 - 6087
反应条件
in tetrahydrofuran; water
参考文献
Bristol-Myers Squibb Company
Patent: US6011029 A1, 2000 ;
参考文献
I.G. Farbenind.
Patent: CH162148 , 1932 ;
反应条件
1: potassium permanganate; magnesium sulfate; water
View Scheme
参考文献
I.G. Farbenind.
Patent: CH162148 , 1932 ;
反应条件
1: benzene; AlCl3
2: KMnO4; MgSO4; aqueous pyridine
3: aqueous HCl
View Scheme
参考文献
Barnett et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 4583,4585
反应条件
1: 26 percent / Pd(PPh3)4; aq. NaHCO3 / 1,2-dimethoxy-ethane / Heating
2: 47 percent / aq. NaOH; aq. H2O2 / 0.5 h / 50 °C
View Scheme
参考文献
Gerard, Anne-Laure; Lisowski, Vincent; Rault, Sylvain
Tetrahedron, 2005 , vol. 61, # 25 p. 6082 - 6087
反应条件
1: 73 percent / H2SO4
2: 26 percent / Pd(PPh3)4; aq. NaHCO3 / 1,2-dimethoxy-ethane / Heating
3: 47 percent / aq. NaOH; aq. H2O2 / 0.5 h / 50 °C
View Scheme
参考文献
Gerard, Anne-Laure; Lisowski, Vincent; Rault, Sylvain
Tetrahedron, 2005 , vol. 61, # 25 p. 6082 - 6087
反应条件
1: 90 percent / NH2OH*HCl; aq. HCl; Na2SO4
2: 73 percent / H2SO4
3: 26 percent / Pd(PPh3)4; aq. NaHCO3 / 1,2-dimethoxy-ethane / Heating
4: 47 percent / aq. NaOH; aq. H2O2 / 0.5 h / 50 °C
View Scheme
参考文献
Gerard, Anne-Laure; Lisowski, Vincent; Rault, Sylvain
Tetrahedron, 2005 , vol. 61, # 25 p. 6082 - 6087
反应条件
1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 0.17 h / 200 °C
2: lithium hydroxide hydrate / tetrahydrofuran / 20 °C
3: trifluoroacetic acid / dichloromethane
View Scheme
参考文献
Steinmetz, Heinrich; Zander, Wiebke; Shushni, Muftah A.M.; Jansen, Rolf; Gerth, Klaus; Dehn, Richard; Draeger, Gerald; Kirschning, Andreas; Mueller, Rolf
ChemBioChem, 2012 , vol. 13, # 12 p. 1813 - 1817
