7-硝基-2,3,4,5-四氢-1H-苯并[b]氮杂卓合成路线 （共 3 条）
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran
T=20 - 40°C; 16.25 h;
2: With hydrogenchloride in tetrahydrofuran
T=10°C;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2004/69245 A1, 2004 ;
Location in patent: Page/Page column 105 ;
反应条件
nitric acid in tetrahydrofuran; n-heptane; dichloromethane; sulfuric acid
参考文献
Johnson, Paul D.; Aristoff, Paul Adrian; Poel, Toni-Jo; Thomasco, Lisa Marie
Patent: US2002/133021 A1, 2002 ;
反应条件
1: 70 percent / HNO3; H2SO4 / 0 - 5 °C
2: 85 percent / BH3 / tetrahydrofuran / 60 °C
View Scheme
参考文献
Johnson, Paul D.; Aristoff, Paul A.; Zurenko, Gary E.; Schaadt, Ronda D.; Yagi, Betty H.; Ford, Charles W.; Hamel, Judith C.; Stapert, Douglas; Moerman, Judy K.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4197 - 4200
