(2-(4-(三氟甲基)苯基)噻唑-4,5-二基)二甲醇合成路线 （共 3 条）
反应条件
sodium tetrahydroborate; acetic acid in tetrahydrofuran
T=45 - 50°C; 3 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/26849 A1, 2004 ;
Location in patent: Page 8; 9 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=-15 - -10°C; 1 h;
参考文献
Guo, Jiasheng; Erickson, Greg A.; Fitzgerald, Russ N.; Matsuoka, Richard T.; Rafferty, Stephen W.; Sharp, Matthew J.; Sickles, Barry R.; Wisowaty, James C.
Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8302 - 8305
反应条件
1: 83 percent / ethanol / 6 h / 67 - 69 °C
2: 81 percent / lithium aluminium hydride / tetrahydrofuran / 1 h / -15 - -10 °C
View Scheme
参考文献
Guo, Jiasheng; Erickson, Greg A.; Fitzgerald, Russ N.; Matsuoka, Richard T.; Rafferty, Stephen W.; Sharp, Matthew J.; Sickles, Barry R.; Wisowaty, James C.
Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8302 - 8305
