4-(5-异喹啉)-1-哌嗪羧酸 1,1-二甲基乙酯合成路线 （共 5 条）
反应条件
tris(dibenzylideneacetone)dipalladium (0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate in toluene
T=80°C; Buchwald-Hartwig reaction;
参考文献
Kling, Andreas; Lange, Udo E. W.; Mack, Helmut; Bakker, Margot H. M.; Drescher, Karla U.; Hornberger, Wilfried; Hutchins, Charles W.; Moeller, Achim; Mueller, Reinhold; Schmidt, Martin; Unger, Liliane; Wicke, Karsten; Schellhaas, Kurt; Steiner, Gerd
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 24 p. 5567 - 5573
反应条件
sodium hydroxide in 1,4-dioxane
Cooling with ice;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J.P.; SMITH II, Leon M.; SRIVASTAVA, Shefali
Patent: WO2013/56060 A1, 2013 ;
Location in patent: Paragraph 00269 ;
反应条件
1: 52 percent / NBS; H2SO4 / -20 °C
2: 72 percent / NaO(t)Bu; BINAP; Pd2(dba)3 / toluene / 80 °C
View Scheme
参考文献
Kling, Andreas; Lange, Udo E. W.; Mack, Helmut; Bakker, Margot H. M.; Drescher, Karla U.; Hornberger, Wilfried; Hutchins, Charles W.; Moeller, Achim; Mueller, Reinhold; Schmidt, Martin; Unger, Liliane; Wicke, Karsten; Schellhaas, Kurt; Steiner, Gerd
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 24 p. 5567 - 5573
反应条件
1: NaOAc; BINAP; Pd(dba)2
View Scheme
参考文献
Fisher, Matthew J.; Backer, Ryan T.; Husain, Saba; Hsiung, Hansen M.; Mullaney, Jeffrey T.; O'Brian, Thomas P.; Ornstein, Paul L.; Rothhaar, Roger R.; Zgombick, John M.; Briner, Karin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4459 - 4462
参考文献
Fisher, Matthew J.; Backer, Ryan T.; Husain, Saba; Hsiung, Hansen M.; Mullaney, Jeffrey T.; O'Brian, Thomas P.; Ornstein, Paul L.; Rothhaar, Roger R.; Zgombick, John M.; Briner, Karin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4459 - 4462
