外消旋-2-(2-氯苯基)-(6,7-二氢-4H-噻吩并[3,2-c]吡啶-5-基)乙腈合成路线 （共 12 条）
反应条件
1: 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; water in butan-1-ol
T=115°C; 8 h; Heating / reflux;
2: With hydrogenchloride in water; butan-1-ol
pH=9 - 11;
3: dimethyl sulfate in water; butan-1-ol
T=20 - 45°C; pH=9; 15.5 h; Heating / reflux;
参考文献
ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.; CHENGDU ORGANIC CHEMICLAS CO., LTD CHINESE ACADEMY OF SCIENCES
Patent: US2008/249311 A1, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
1.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water; butan-1-ol / 12 h / |Reflux
2.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / methanol; water / 0.5 h / |Reflux
2.2: 12 h / 40 °C
View Scheme
参考文献
KANDULA, Mahesh
Patent: WO2013/168022 A1, 2013 ;
