1: methanol; dimethyl sulfate With sulfuric acid T=25 - 38°C; 3 h; Heating / reflux; 2: (+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide T=40 - 66°C; 60 h;

1: With benzenesulfonic Acid T=70 - 75°C; 10 - 24 h; 2: With sodium hydrogencarbonate in methanol; dichloromethane; water Product distribution / selectivity;