2,3-二甲基-6-硝基吲唑合成路线 （共 15 条）
反应条件
1: 3-methyl-6-nitro-1H-indazole With 1,4-diaza-bicyclo[2.2.2]octane in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: carbonic acid dimethyl ester in N,N-dimethyl-formamide 6 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 4 p. 1108 - 1110
反应条件
1: trimethyl orthoformate With boron trifluoride diethyl etherate in dichloromethane T=-30 - 0°C; 0.25 h; 2: 3-methyl-6-nitro-1H-indazole in dichloromethane T=-70 - 20°C; 17.25 h; 3: With sodium hydrogencarbonate in dichloromethane; water Product distribution / selectivity;
参考文献
US2008/293691 A1, ;
Page/Page column 8 ;
反应条件
in acetone T=20°C; 3 h; Product distribution / selectivity;
参考文献
WO2007/64753 A2, ;
Page/Page column 24-25 ;
反应条件
sulfuric acid in dimethyl sulfoxide T=50°C; 72 h; Product distribution / selectivity;
参考文献
WO2007/64753 A2, ;
Page/Page column 25-26 ;
反应条件
1: in dichloromethane; dimethyl sulfoxide T=25 - 70°C; 7 h; Heating / reflux; 2: With sodium hydrogencarbonate in dichloromethane; water; dimethyl sulfoxide T=20°C; Product distribution / selectivity;
参考文献
US2008/293691 A1, ;
Page/Page column 8 ;
反应条件
1: With sulfuric acid in dimethyl sulfoxide T=50°C; 72 h; 2: With sodium hydrogencarbonate in water; dimethyl sulfoxide T=20°C;
参考文献
WO2009/62658 A1, ;
Page/Page column 34; 1/10 ;
WO 2009/062658 A1
反应条件
1: 3-methyl-6-nitro-1H-indazole With trifluorormethanesulfonic acid in dichloromethane T=25 - 35°C; Inert atmosphere; 2: methyl 2,2,2-trichloroacetimidate in dichloromethane T=20°C; Inert atmosphere; regioselective reaction;
参考文献
Tetrahedron Letters, , vol. 54, # 13 p. 1661 - 1663
反应条件
1: trimethyl orthoformate With boron trifluoride diethyl etherate in dichloromethane T=-70 - 0°C; 0.25 h; 2: 3-methyl-6-nitro-1H-indazole in dichloromethane T=-70 - 20°C; 17.25 h; Product distribution / selectivity;
参考文献
WO2007/64753 A2, ;
Page/Page column 25 ;
反应条件
dimethyl sulfoxide in dichloromethane T=25 - 70°C; 7 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2007/64753 A2, ;
Page/Page column 26 ;
反应条件
1: trimethyl orthoformate With boron trifluoride diethyl etherate in dichloromethane T=-30 - 0°C; 0.283333 h; 2: nitro indazole in dichloromethane T=-70 - 20°C; 17.25 h; 3: With sodium hydrogencarbonate in dichloromethane; water Product distribution / selectivity;
参考文献
WO2006/20564 A1, ;
Page/Page column 12-13 ;
