N-(2-氯嘧啶-4-基)- 2,3-二甲基-2H-吲唑-6-胺合成路线 （共 6 条）
反应条件
sodium hydrogencarbonate in tetrahydrofuran; ethanol T=75°C;
参考文献
Chemical Biology and Drug Design, , vol. 83, # 3 p. 306 - 316
反应条件
sodium hydrogencarbonate in tetrahydrofuran; ethanol T=85°C; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 15 p. 4632 - 4640
反应条件
1.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 0.25 h / 20 °C 1.2: 6 h / |Reflux 2.1: palladium 10 on activated carbon; hydrogen / ethanol / 12 h / 20 °C 3.1: sodium hydrogencarbonate / ethanol / 6 h / 85 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 4 p. 1108 - 1110
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol / 12 h / 20 °C 2: sodium hydrogencarbonate / ethanol / 6 h / 85 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 4 p. 1108 - 1110
反应条件
1: N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine With caesium carbonate in N,N-dimethyl-formamide T=20 - 25°C; 0.166667 h; 2: methyl iodide in N,N-dimethyl-formamide T=20 - 30°C; 1.16667 - 2.16667 h; Product distribution / selectivity;
参考文献
US2008/293691 A1, ;
Page/Page column 10 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=135°C; 6 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2007/64753 A2, ;
Page/Page column 30 ;
