N-(2-氯嘧啶-4-基)-N-甲基-2,3-二甲基-2H-吲唑-6-胺合成路线 （共 9 条）
反应条件
1: N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine With caesium carbonate in N,N-dimethyl-formamide T=20 - 25°C; 0.166667 h; 2: methyl iodide in N,N-dimethyl-formamide T=20 - 30°C; 1.16667 - 2.16667 h; Product distribution / selectivity;
参考文献
US2008/293691 A1, ;
Page/Page column 10 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=135°C; 6 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2007/64753 A2, ;
Page/Page column 30 ;
反应条件
1: N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine With caesium carbonate in N,N-dimethyl-formamide T=20 - 25°C; 0.166667 h; 2: methyl iodide in N,N-dimethyl-formamide T=20 - 30°C; 0.166667 h; 3: With water in N,N-dimethyl-formamide T=20 - 40°C; 1.16667 h; Product distribution / selectivity;
参考文献
WO2007/64753 A2, ;
Page/Page column 30 ;
反应条件
1: N-(2-chloro-4-pyrimidinyl)-N-(3-methyl-1H-indazol-6-yl)amine With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 15 p. 4632 - 4640
反应条件
sodium carbonate in N,N-dimethyl-formamide T=100°C; 3 h; Inert atmosphere;
参考文献
Letters in Organic Chemistry, , vol. 9, # 4 p. 276 - 279
反应条件
1: sodium hydride / methanol / 20 °C 2: sodium tetrahydroborate / methanol / 3 h / 20 °C 3: sodium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere View Scheme
参考文献
Letters in Organic Chemistry, , vol. 9, # 4 p. 276 - 279
反应条件
1: sulfuric acid / N,N-dimethyl-formamide; toluene / 3 h / Reflux 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol 3: sodium hydride / methanol / 20 °C 4: sodium tetrahydroborate / methanol / 3 h / 20 °C 5: sodium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere View Scheme
参考文献
Letters in Organic Chemistry, , vol. 9, # 4 p. 276 - 279
反应条件
1: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol 2: sodium hydride / methanol / 20 °C 3: sodium tetrahydroborate / methanol / 3 h / 20 °C 4: sodium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere View Scheme
参考文献
Letters in Organic Chemistry, , vol. 9, # 4 p. 276 - 279
反应条件
1: acetic acid; sodium nitrite / water / 0.5 h / 35 °C 2: sulfuric acid / N,N-dimethyl-formamide; toluene / 3 h / Reflux 3: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol 4: sodium hydride / methanol / 20 °C 5: sodium tetrahydroborate / methanol / 3 h / 20 °C 6: sodium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere View Scheme
参考文献
Letters in Organic Chemistry, , vol. 9, # 4 p. 276 - 279
