5'-氨基-2,3'-联噻吩-4'-羧酸甲酯合成路线 (共 3 条)
反应条件
sulfuric acid
Heating / reflux; Product distribution / selectivity;
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: WO2007/102679 A1, 2007 ;
Location in patent: Page/Page column 49-50 ;
WO 2007/102679 A1
反应条件
piperidine; sulfur in ethanol
T=80°C; Gewald Aminoheterocycles Synthesis;
参考文献
Park, Chun-Ho; Lee, Chulho; Yang, Jee Sun; Joe, Bo-Young; Chun, Kwangwoo; Kim, Hyuntae; Kim, Hye Yun; Kang, Jong Soon; Lee, Jangik I.; Kim, Myung-Hwa; Han, Gyoonhee
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 12 p. 2655 - 2660
反应条件
1: ammonium acetate / acetic acid; toluene / |Reflux
2: sulfur; piperidine / ethanol / 80 °C
View Scheme
参考文献
Park, Chun-Ho; Lee, Chulho; Yang, Jee Sun; Joe, Bo-Young; Chun, Kwangwoo; Kim, Hyuntae; Kim, Hye Yun; Kang, Jong Soon; Lee, Jangik I.; Kim, Myung-Hwa; Han, Gyoonhee
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 12 p. 2655 - 2660