2-氨基-5-溴三氟甲苯合成路线 （共 18 条）
反应条件
ammonium chloride; iron
参考文献
Junge, Kathrin; Wendt, Bianca; Shaikh, Nadim; Beller, Matthias
Chemical Communications, 2010 , vol. 46, # 10 p. 1769 - 1771
反应条件
[iridium(III)(2-phenylpyridine)3] in N,N-dimethyl-formamide T=20°C; Inert atmosphereIrradiationSchlenk technique;
参考文献
Xie, Jin; Yuan, Xiangai; Abdukader, Ablimit; Zhu, Chengjian; Ma, Jing
Organic Letters, 2014 , vol. 16, # 6 p. 1768 - 1771
反应条件
C6mim(1+)Br(1-); copper(ll) bromide 1 h; regioselective reaction;
参考文献
Wang, Han; Wen, Kun; Nurahmat, Nurbiya; Shao, Yan; Zhang, He; Wei, Chao; Li, Ya; Shen, Yongjia; Sun, Zhihua
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 744 - 748
反应条件
1: sulfuric acid; concentrated aqueous nitric acid 2: SnCl2; aq.-ethanolic HCl View Scheme
参考文献
Bachman; Lewis
Journal of the American Chemical Society, 1947 , vol. 69, p. 2022
反应条件
1: SbCl5 / Bromierung; Einleiten von Chlor 2: concentrated H2SO4; concentrated HNO3 / 60 °C 3: iron; ammonium chloride View Scheme
参考文献
Bachman; Lewis
Journal of the American Chemical Society, 1947 , vol. 69, p. 2022
反应条件
1: Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuBr in wss. HBr 2: concentrated H2SO4; concentrated HNO3 / 60 °C 3: iron; ammonium chloride View Scheme
参考文献
Bachman; Lewis
Journal of the American Chemical Society, 1947 , vol. 69, p. 2022
反应条件
1.1: 2.73 g / I2; tert-butyl nitrite / acetonitrile / 16 h / 20 °C 2.1: i-propylmagnesium chloride / tetrahydrofuran / 2 h / -20 °C 2.2: 66.4 percent / tetrahydrofuran / 1 h / -20 °C View Scheme
参考文献
Hattori, Yoshihide; Yamamoto, Hitoshi; Ando, Hideya; Kondoh, Hirofumi; Asano, Tomoyuki; Kirihata, Mitsunori; Yamaguchi, Yoshihiro; Wakamiya, Tateaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 5 p. 2198 - 2205
反应条件
tert.-butylnitrite; iodine in acetonitrile T=60°C; P=5171.62 Torr; 0.416667 h; Continuous flow reactor;
参考文献
Malet-Sanz, Laia; Madrzak, Julia; Holvey, Rhian S.; Underwood, Toby
Tetrahedron Letters, 2009 , vol. 50, # 52 p. 7263 - 7267
反应条件
potassium carbonate in dichloromethane T=14 - 20°C; 1.5 h; Inert atmosphereLarge scale reaction;
参考文献
Li, Xun; Ng, Raymond A.; Zhang, Yongzheng; Russell, Ronald K.; Sui, Zhihua
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 652 - 655
反应条件
in chloroform T=0 - 20°C;
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth
Patent: WO2011/97491 A1, 2011 ;
Location in patent: Page/Page column 158 ;
