2-氨基-5-溴三氟甲苯合成路线 （共 18 条）
反应条件
in tetrahydrofuran T=0 - 25°C; 2.16667 h;
参考文献
Hoffmann-La Roche Inc.
Patent: US6369232 B1, 2002 ;
Location in patent: Page column 57 ;
反应条件
acetic anhydride in tetrahydrofuran
参考文献
Sidduri, Achyutharao
Patent: US2002/35266 A1, 2002 ;
反应条件
copper (I) cyanide in 1-methyl-pyrrolidin-2-one
参考文献
Chen, Jyh-Chien; Chiang, Chi-Jui; Chiu, Jen-Chun; Ju, Jyh-Jong
Chemical Communications, 2012 , vol. 48, # 62 p. 7756 - 7758
反应条件
in 1-methyl-pyrrolidin-2-one Reflux;
参考文献
Chen, Jyh-Chien; Liu, Yen-Chun; Ju, Jyh-Jong; Chiang, Chi-Jui; Chern, Yaw-Tern
Polymer, 2011 , vol. 52, # 4 p. 954 - 964
反应条件
1: 12 h / 25 °C 2: concd. H2SO4, concd. HNO3 / 0 - 20 °C 3: concd. HCl / Heating 4: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth
Patent: WO2011/97491 A1, 2011 ;
反应条件
1: 12 h / 25 °C 2: concd. H2SO4, concd. HNO3 / 0 - 20 °C 3: concd. HCl / Heating View Scheme
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth
Patent: WO2011/97491 A1, 2011 ;
反应条件
N-chloro-succinimide in acetonitrile
T=80°C; 2 h;
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth
Patent: WO2011/97491 A1, 2011 ;
Location in patent: Page/Page column 150 ;
反应条件
{PdCl2[(t-Bu)2PCl]2}; triethylamine in toluene
2 h; Inert atmosphereReflux;
参考文献
Wheaton, Susan L.; Kabir, S.M. Humanayun; Zhang, Haiwen; Vogels, Christopher M.; Decken, Andreas; Westcott, Stephen A.
Central European Journal of Chemistry, 2010 , vol. 8, # 4 p. 725 - 731
