2-氨基-5-氯三氟甲苯合成路线 （共 18 条）
反应条件
1: Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuSO4 oder CuCl in wss. HCl in der Waerme 2: tin; aqueous hydrochloric acid View Scheme
参考文献
Whalley
Journal of the Chemical Society, 1949 , p. 3016,3019
反应条件
sodium hydroxide; sodium formate; palladium on charcoal in water
参考文献
Imperial Chemical Industries Limited
Patent: US4022795 A1, 1977 ;
反应条件
Raney aluminium-nickel alloy; water; sodium hydroxide in dimethoxymethane T=25°C; 17 h;
参考文献
Weidlich, Tomas; Prokes, Lubomir
Central European Journal of Chemistry, 2011 , vol. 9, # 4 p. 590 - 597
参考文献
Zhu, You-Quan; Wu, Chao; Li, Hua-Bin; Zou, Xiao-Mao; Si, Xue-Kai; Hu, Fang-Zhong; Yang, Hua-Zheng
Journal of Agricultural and Food Chemistry, 2007 , vol. 55, # 4 p. 1364 - 1369
反应条件
1: 92 percent / 12 h / 25 °C
2: 53 percent / concd. H2SO4, concd. HNO3 / 0 - 20 °C
3: concd. HCl / Heating
4: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C
View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
hydroxylamine hydrochloride
参考文献
Xie, Jin; Yuan, Xiangai; Abdukader, Ablimit; Zhu, Chengjian; Ma, Jing
Organic Letters, 2014 , vol. 16, # 6 p. 1768 - 1771
反应条件
1: With sulfuric acid; sodium nitrite in water
T=0°C; 3 h;
2: With urea in water
1.16667 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/92835 A1, 2005 ;
Location in patent: Page/Page column 37 ;
WO 2005/092835 A1
反应条件
copper; potassium carbonate
参考文献
Endel'man,E.S. et al.
Pharmaceutical Chemistry Journal, 1973 , vol. 7, # 12 p. 755 - 759
Khimiko-Farmatsevticheskii Zhurnal, 1973 , vol. 7, # 12 p. 15 - 19
