反应条件
1: 2,4,6-trimethoxypyrimidine With n-butyllithium in tetrahydrofuran; diethyl ether; hexane
T=-30°C; 1.5 h; Inert atmosphere;
2: formic acid ethyl ester in tetrahydrofuran; diethyl ether; hexane
T=-70°C; 1 h; Inert atmosphere;
3: With hydrogenchloride in tetrahydrofuran; diethyl ether; ethanol; hexane; water
T=-70 - 0°C; Inert atmosphere;
参考文献
Arai, Satoshi; Okamura, Toshiya; Takeoka, Shinji
Tetrahedron Letters, 2010 , vol. 51, # 39 p. 5177 - 5180