2-甲基-2-丙基4-溴-2-甲基苯甲酸酯合成路线 （共 4 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tert-butyl alcohol
T=20°C; 18 h;
参考文献
CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.
Patent: WO2013/75083 A1, 2013 ;
Location in patent: Paragraph 00521; 00522; 00579; 00580 ;
反应条件
1: 2-methyl-4-bromo-benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 3 h;
2: potassium tert-butylate in tetrahydrofuran
T=2 - 20°C; 0.5 h;
参考文献
SYNGENTA PARTICIPATIONS AG; EL QACEMI, Myriem; CASSAYRE, Jerome Yves; TOUEG, Julie Clementine; RENOLD, Peter; PITTERNA, Thomas
Patent: WO2011/101229 A1, 2011 ;
Location in patent: Page/Page column 73 ;
反应条件
in tetrahydrofuran
T=2 - 20°C; 0.5 h;
参考文献
SYNGENTA PARTICIPATIONS AG
Patent: WO2009/80250 A2, 2009 ;
Location in patent: Page/Page column 52 ;
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C
2: tetrahydrofuran / 5 - 20 °C
View Scheme
参考文献
SYNGENTA PARTICIPATIONS AG; TOUEG, Julie Clementine; SMEJKAL, Tomas; WENDEBORN, Sebastian Volker; CASSAYRE, Jérôme Yves; EL QACEMI, Myriem; BREIT, Bernhard; DIAB, Lisa; MONDIERE, Régis Jean Georges; POIRIER, Nicolas
Patent: WO2013/26724 A1, 2013 ;
