1: With potassium acetate in 1,4-dioxane 0.25 h; 2: With tri-cyclo-hexyl-phosphine; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane T=80°C; 16.25 h;

1: 3-Bromo-5-methoxypyridine With n-butyllithium in diethyl ether; hexane T=-80°C; Inert atmosphere; 2: With boric acid trimethyl ester in diethyl ether; hexane T=-80 - 20°C; 12 h; Inert atmosphere; 3: 2,3-dimethylbutane-2,3-diol With acetic acid in diethyl ether; hexane T=20°C; 6 h; Inert atmosphere;

1.1: methanol / 48 h / 140 °C / Autoclave 2.1: n-butyllithium / diethyl ether; hexane / -80 °C / Inert atmosphere 2.2: 12 h / -80 - 20 °C / Inert atmosphere 2.3: 6 h / 20 °C / Inert atmosphere View Scheme