反应条件
1: 2-(4-iodopyrazol-1-yloxy)benzonitrile With isopropylmagnesium chloride in tetrahydrofuran T=-78°C; 0.516667 h; 2: With zinc(II) chloride in tetrahydrofuran T=-78 - 20°C; 3: 1-(iodo)-4-methylbenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; Negishi cross-coupling; 18 h;
参考文献
Kristensen, Jesper L; Vedso, Per; Begtrup, Mikael
Tetrahedron, 2002 , vol. 58, # 12 p. 2397 - 2404